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It increased fat-free mass in a two-year study of healthy older adults, but that increase did not result in changes in strength or function. So while a body-composition number moved, the trial did not demonstrate meaningful functional or strength benefit

138 However, excessive or chronic inflammation exhausts immune cells due to the constant exposure of T antigens, causing dysfunction with the maintained expression of inhibitory receptors such as PD1 and CTLA4, which alter transcription

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